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When you find yourself outnumbered, just simply run into the closest room. Don't waste more powerful ammo on weaker enemies (for example, don't waste Magnum Rounds on zombies). Don't waste ammo on enemies like miniature spiders and bees. Always drop off your Ink Ribbons into the nearest item box after saving to save inventory space. In the beginning of the game, try saving ammo by stabbing enemies on the ground with the Combat Knife.
Try to avoid enemies and fight only when absolutely necessary, as ammo is not available in great abundance. Always reload by going into your inventory screen, selecting the weapon, and combining it with that weapon's ammo (do not use the auto-reload feature). In Rebirth Mode, he'll have thirty Handgun Bullets and fourteen Shotgun Shells in one of the item boxes. Must find the broken shotgun and defuse a trap before taking the shotgun. Can’t read notes and play the piano he must be helped by Rebecca. Only starts off with a Combat Knife and First Aid Spray (and an extra First Aid Spray in Rebirth Mode). Must use the Sword Key to unlock three of the Mansion's rooms. Can get the Flamethrower but not the much more useful Bazooka. Rebecca will sometimes heal Chris for free. Has to unlock drawers with Small Keys instead of the Lockpick (each Small Key takes up one inventory slot). Has only six inventory spaces instead of eight. In Rebirth Mode, she'll have sixty Handgun Bullets, twenty-eight Shotgun Shells, a Green, Blue and Red Herb in one of the item boxes. Can get the shotgun sooner, as even triggering the trap, she will be rescued by Barry. Starts off with a Beretta M92FS, First Aid Spray, and Combat Knife (and an extra First Aid Spray in Rebirth Mode). Can get the Bazooka but not the Flamethrower (which, however, is almost useless). Barry helps Jill several times throughout the game. Receives a Lockpick that will open almost every major door and any drawer.
Has eight inventory spaces instead of six. All of their differences are listed below: If this is your first time playing a Resident Evil game, you'll definitely want to start off as Jill, as she has more benefits than Chris. Jill and Chris are two completely different characters, and you may want to decide which is better for you.
Once you start the game, you'll be asked to choose either Chris Redfield or Jill Valentine. For the Nintendo DS version, either select "Classic" mode (the original game) or "Rebirth" mode (a new single player experience). If you have the Director's Cut edition, either select "Original" (the original game), "Beginner" (still the original but much easier), or "Arranged" (a completely new story mode). If you have the original Resident Evil, just select "New Game" to start right away.